Tuesday, November 11, 2008

R.I.P. Marijuana Receptor Weight Loss Drugs

Not sure if you've heard of them since they never really hit North American shores.

They were a class of drugs that worked on the endocannabinoid receptors and multiple drugs companies were working on obesity drugs based on blocking CB-1 receptors and in so doing, decrease caloric intake.

The drugs were actually fairly effective, one of them had even been released, but unfortunately there was an unacceptably high incidence of adverse psychiatric affects including suicidal ideation and less than 2 years after their much bally-hoo'ed launch, they've been permanently pulled from the market and the drug companies have all quashed their development.

Could someone please invent a safe and efficacious medication for weight management?


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  1. Or people could stop eating like pigs and try some basic exercise. Imagine that...WORKING for desired results!

  2. What folks like Mr. Five Star seem to forget is that obesity kills people and attitudes that suggest that all you need to do is eat less and exercise more are about as useful as telling people that to make lots of money all they have to do is buy low and sell high in the stock market.

    Good for you Mr. Five Star, for doing it on your own but pardon me if I'd still like to get my hands on a medication that will help people live longer, improve their comorbid medical conditions and their quality of life.

  3. Anonymous4:33 pm

    Thank you, Dr. Freedhoff. I eat properly, but have trouble losing weight as I can't exercise much due to excessive pain with knee problems. Yes, it would be easier to exercise if I weighed less, but without something like a drug to help with the initial loss, it's a never ending battle. Something Mr. Five Star would never understand I fear.

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  5. I think you are right now a days noone has time for exercise or yoga for loosing over weight so it is the best option for reduce weight taking some pills and try it.